La EM, Garbinsky D, Hunter S, Poston S, Novy P, Ghaswalla P. Individual and state-level factors associated with receipt of multiple recommended adolescent vaccines in the United States. Presented at the IDWeek 2020 Virtual Conference; October 2020.

BACKGROUND: The Advisory Committee on Immunization Practices (ACIP) routinely recommends several adolescent vaccines, including human papillomavirus (HPV); quadrivalent meningococcal conjugate (MenACWY); and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccines. Limited data are available on the percentage of adolescents receiving this complement of ACIP-recommended vaccines and factors that may increase likelihood of completion.

METHODS: This study used 2015-18 pooled National Immunization Survey-Teen (NIS-Teen) data to estimate national and state-level completion rates by age 17 of a two-dose MenACWY series, two- or three- dose HPV series (depending on age at first vaccination), and a Tdap vaccine, using multivariable logistic regression modeling to adjust for individual characteristics. NIS-Teen data were then combined with public state-level data to construct a multilevel model evaluating effects of both individual- and state-level factors on completion.

RESULTS: After adjusting for individual-level factors, the national completion rate for these ACIP-recommended vaccines by age 17 was 30.6% (95% confidence interval [CI]: 30.1-31.0%). However, rates for individual states varied substantially, from 11.3% in Idaho (CI: 6.9-18.0%) to 56.4% in Rhode Island (CI: 49.8-62.8%). In the multilevel model, individual characteristics associated with increased likelihood of receiving the recommended vaccines by age 17 included female gender, black or Hispanic race, Medicaid coverage (vs. private/other), last provider visit at age 16 or 17, generally having ≥1 provider visit in last year, and receiving a provider recommendation for HPV vaccination. Residing in a state with a MenACWY vaccination mandate for elementary and secondary schools was the only state-level variable that significantly increased the likelihood of completion (odds ratio: 1.6; CI: 1.2-2.3).

CONCLUSION: Recommended adolescent vaccine completion rates are suboptimal and highly variable across states. Provider recommendations, visits at 16-17 years of age, and state mandates for MenACWY are implementable strategies associated with completion of recommended adolescent vaccines.