Dermatology

Arana A, Pottegard A, Kuiper J, Booth H, Reutfors J, Calingaert B, Lund LC, Crellin E, Schmitt-Egenolf M, Kaye J, Gembert K, Rothman K, Kieler H, Dedman D, Houben E, Gutierrez L, Hallas J, Perez-Gutthann S. Long-term risk of skin cancer and lymphoma in users of topical tacrolimus and pimecrolimus: final results from the extension of the cohort study Protopic Joint European Longitudinal Lymphoma and Skin Cancer Evaluation (JOELLE). Clin Epidemiol. 2021 Dec 29;2021(13):1141-53. doi: 10.2147/CLEP.S331287


PURPOSE: Evidence is insufficient to infer whether topical calcineurin inhibitors (TCIs; tacrolimus and pimecrolimus) cause malignancy. The study objective was to estimate the long-term risk of skin cancer and lymphoma associated with topical TCI use in adults and children, separately.

Pandya AG, Amoloja T, Bibeau K, DiBenedetti D, Kosa K, Butler K, Kornacki D, Ezzedine K. Assessing patients' experiences with vitiligo from qualitative interviews. Poster presented at the 2022 Virtual Maui Derm for Dermatologists; January 24, 2022. Maui, HI.


Abstract not available at this time.

Wyrwich KW, Winnette R, Bender R, Gandhi K, Williams N, Harris N, Nelson L. Validation of the alopecia areata patient priority outcomes (AAPPO) questionnaire in adults and adolescents with alopecia areata. Dermatol Ther. 2022 Jan;12(1):149-66. doi: 10.1007/s13555-021-00648-z


Winnette R, Wyrwich K, Bender R, Gandhi K, Williams N, Harris N, Nelson L. Validation of AAPPO Questionnaire in adults and adolescents with alopecia areata. Poster presented at the Virtual ISPOR 2021 Conference; May 2021.


OBJECTIVES: To establish the domain structure and scoring, and evaluate the psychometric properties of the Alopecia Areata Patient Priority Outcomes (AAPPO) questionnaire in adults and adolescents with Alopecia Areata (AA).

Chisaguano AM, Montes R, Perez-Berezo T, Castellote AI, Guerendiain M, Bustamante M, Morales E, Garcia-Esteban R, Sunyer J, Franch A, Lopez-Sabater MC. Gene expression of desaturase (FADS1 and FADS2) and elongase (ELOVL5) enzymes in peripheral blood: association with polyunsaturated fatty acid levels and atopic eczema in 4-year-old children. PLoS One. 2013 Oct 22;8(10):e78245. doi: 10.1371/journal.pone.0078245


Houghton K, Patil D, Gomez B, Feldman SR. Correlation between change in psoriasis area and severity index and dermatology life quality index in patients with psoriasis: pooled analysis from four phase 3 clinical trials of Secukinumab. Dermatol Ther. 2021 Aug;11(4):1373-84. doi: 10.1007/s13555-021-00564-2


INTRODUCTION: Patients with psoriasis (PsO) experience impaired health-related quality of life due to physical and psychosocial burdens.

Husni ME, Bozyczko M, Wolin D, Sweeney C, Davenport E, Hass S, Yi E, Hur P, Grinnell-Merrick L. A prospective, longitudinal study to evaluate real-world patient experiences and treatment satisfaction with secukinumab for psoriatic arthritis. Poster presented at the Virtual EULAR 2021 Congress; June 2, 2021. [abstract] Ann Rheum Dis. 2021 Jun; 80(Suppl 1):808-9.


BACKGROUND: Psoriatic arthritis (PsA) is an inflammatory disease that impairs quality of life. Despite therapeutic advances, up to a third of patients do not respond or are unable to sustain a treatment response. Thus, data on patient treatment experience in PsA is critical.

Arana A, Pottegard A, Kuiper JG, Crellin E, Reutfors J, Schmitt-Egenolf M, Lund LC, Houben E, Booth H, Calingaert B, Kaye JA, Gembert K, Rothman KJ, Dedman D, Kieler H, Gutierrez L, Hallas J, Perez-Gutthann S. To what extent are topical tacrolimus or pimecrolimus associated with an increased risk of skin cancer and lymphoma? Long-term results from JOELLE study. Poster presented at the 2020 Virtual European Academy of Dermatology and Venereology Conference; October 29, 2020. Previously presented at the 2020 36th ICPE International Virtual Conference on Pharmacoepidemiology & Therapeutic Risk Management.


BACKGROUND: Observations of transplant recipients receiving systemic calcineurin inhibitors have raised concern of a potentially increased risk of lymphoma and skin cancer with topical use of tacrolimus (TAC) or pimecrolimus (PIM) for atopic dermatitis.

Dalal G, Wright SJ, Vass CM, Davison NJ, Vander Stichele G, Smith CH, Griffiths CEM, Payne K, PSORT consortium. Patient preferences for stratified medicine in psoriasis: a discrete choice experiment. Br J Dermatol. 2021 Nov;185(5):978-87. doi: 10.1111/bjd.20482


Feldman SR, Poulos C, Gilloteau I, Mange B, Boehm K, Boeri M, Naatz M, Augustin M. Exploring determinants of psoriasis patients' treatment choices: a discrete-choice experiment study in the United States and Germany. J Dermatolog Trea. 2021 Feb 3;1-10. doi: 10.1080/09546634.2020.1839007


BACKGROUND: Biologic psoriasis treatments are differentiated by efficacy, side effects, and other attributes.

OBJECTIVE: Determine attributes of biologic psoriasis treatments that drive patients’ treatment choices.

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