Gastroenterology

Ronquest N, La L, Nag A. Characterizing patients with IBD in Japan: epidemiology, symptoms, treatment pathways and humanistic burden. Poster presented at the 2020 Virtual Japan Digestive Disease Week Conference; November 2020.


BACKGROUND: Given the increasing number of therapeutics for inflammatory bowel disease (IBD) in Japan, the objective of the current study was to characterize the patient population, focusing on the epidemiology, symptoms, treatment landscape and humanistic burden of ulcerative colitis (UC) and Crohn’s disease (CD) in Japan.

Vickers A, Nag A, Devine B, Sands BE, Panaccione R, Peyrin-Biroulet L, Danese S, Vermeire S, Gorelick KJ, Goetsch M, Hartley L. Induction of endoscopic response: a network meta-analysis of induction studies comparing ontamalimab with other treatments for moderate-to-severe ulcerative colitis. Poster presented at the 2020 European Crohn's and Colitis Organisation Annual Congress; February 2020. Vienna, Austria.


Vickers A, Nag A, Devine B, Sands BE, Panaccione R, Peyrin-Biroulet L, Danese S, Vermeire S, Gorelick KJ, Goetsch M, Hartley L. Induction of response and remission: a network meta-analysis of induction studies comparing ontamalimab with other treatments for moderate-to-severe ulcerative colitis. Poster presented at the 2020 15th Congress of the European Crohn’s and Colitis Organisation (ECCO); February 2020. Vienna, Austria.


Pring CM, Skelding-Millar L, Goodall RJ. Expectant treatment or cholecystectomy after endoscopic retrograde cholangiopancreatography for choledocholithiasis in patients over 80 years old? Surg Endosc. 2005 Mar;19(3):357-60.


BACKGROUND: It is recommended that most patients between 18-80 years old, who have had an endoscopic retrograde cholangiopancreatography (ERCP) for choledocholithiasis, should be offered cholecystecytomy. However, we were uncertain whether this was the correct advice for patients over 80.

Gilsenan A, Fortuny J, Cainzos-Achirica M, Cantero OF, Flynn RWV, Garcia-Rodriguez L, Harding A, Kollhorst B, Karlsson P, Linner L, MacDonald TM, Odsbu E, Plana E, Ruigomez A, Schink T, Ziemiecki R, Andrews EB. Cardiovascular safety of prucalopride in patients with chronic constipation: a multinational population-based cohort study. Drug Saf. 2019 Oct;42(10):1179-90. doi: 10.1007/s40264-019-00835-0


INTRODUCTION: The serotonin 5-HT4 receptor agonist prucalopride is approved in the European Union for the treatment of chronic constipation. This offered the unique opportunity to include real-world observational data on cardiovascular safety in the new drug application for approval of prucalopride in the USA.

Nag A, Martin SA, Mladsi D, Olayinka-Amao O, Purser M, Vekaria RM. The humanistic and economic burden of chronic idiopathic constipation in the USA: a systematic literature review. Clin Exp Gastroenterol. 2020 Jul 16;(13):255-65. doi: 10.2147/CEG.S239205


Purser M, Bhaila R, Hartley L, Earnshaw S, Nag A. Economic evaluations of biological treatments for moderate-to-severe Crohn's Disease: findings from a systematic literature review. Poster presented at the 2019 United European Gastroenterology UEG Week; October 23, 2019. Barcelona, Spain. [abstract] United European Gastroenterol J. 2019 Oct; 7:907.


Gilsenan A, Fortuny J, Cainzos-Achirica M, Cantero OF, Flynn RW, Garcia-Rodriguez L, Harding A, Kollhorst B, Karlsson P, Linner L, MacDonald TM, Odsbu I, Plana E, Ruigomez A, Schink T, Ziemiecki R, Andrews EB. Cardiovascular safety of prucalopride for chronic constipation: a multinational population-based cohort study. Presented at the 35th ICPE International Conference on Pharmacoepidemiology & Therapeutic Risk Management; August 26, 2019. Philadelphia, PA. [abstract] Pharmacoepidemiol Drug Saf. 2019 Aug 20; 28(S2):33. doi: 10.1002/pds.4864


BACKGROUND: The serotonin 5-HT4 receptor agonist prucalopride is approved in the European Union (EU) for the treatment of chronic constipation, thus providing opportunity to include real-world observational data on cardiovascular safety to support approval of prucalopride in the United States.

Fortuny J, Gilsenan AW, Cainzos-Achirica M, Cantero OF, Flynn RW, Garcia-Rodriguez L, Kollhorst B, Karlsson P, Linner L, MacDonald TM, Plana E, Ruigomez A, Schink T, Ziemiecki R, Andrews EB. Cohort study of the relative incidence of major cardiovascular events among patients initiating prucalopride versus a matched comparator cohort in a multinational study: study design and comparability of cohorts. Poster presented at the 35th ICPE International Conference on Pharmacoepidemiology & Therapeutic Risk Management; August 27, 2019. Philadelphia, PA. [abstract] Pharmacoepidemiol Drug Saf. 2019 Aug 20; 28(S2):627. doi: 10.1002/pds.4864


BACKGROUND: Given prior safety experience with other 5-HT4 agonists, an observational cohort study was conducted to evaluate the cardiovascular (CV) safety of prucalopride in support of approval of prucalopride for chronic constipation (CC) in the United States.

Cainzos-Achirica M, Ruigomez A, MacDonald T, Garcia-Rodriguez L, Fortuny J, Flynn RW, Plana E, Ziemiecki R, Andrews EB, Gilsenan A. Validation of major cardiovascular events in a multi-database post-authorization safety study of prucalopride. Poster presented at the 35th ICPE International Conference on Pharmacoepidemiology & Therapeutic Risk Management; August 26, 2019. Philadelphia, PA. [abstract] Pharmacoepidemiol Drug Saf. 2019 Aug 20; 28(S2):331. doi: 10.1002/pds.4864


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