Diabetes & Endocrine Disorders
Clay B, Pop-Busui R, Januzzi JL, Neveux P, Zhang K, McDade C, Earnshaw S. Economic evaluation of NT-proBNP testing to facilitate prevention of heart failure in adults with type 2 diabetes. Poster presented at the ISPOR 2025; May 14, 2025. Montréal, Canada.
Kovesdy CP, Ebert N, Vizcaya D, Walsh M, Kosiborod MN, Layton JB, Ziemiecki R, Johannes CB, Pladevall-Vila M, Gee PO, Jefferson N, Chicoye A, Lopes M, Thapa BB, Curhan G, Rangel L, Bhartia M, Liu F, Farjat AE, Oberprieler NG. Change in urine albumin-creatinine ratio and occurrence of hyperkalemia in patients initiating finerenone in the United States: a cohort study from the FOUNTAIN platform. Nephron. 2025 Feb 27;1-26. doi: 10.1159/000543923
INTROUDCTION. In 2021, finerenone – a novel, selective non-steroidal mineralocorticoid receptor antagonist – was approved in the US to treat adults with CKD and T2D This study aimed to describe characteristics and short-term outcomes of patients prescribed finerenone since regulatory approval.
Kovesdy CP, Layton JB, Thapa BB, Curhan GC, Rangel LM, Farjat AE, Liu F, Johannes CB, Vizcaya D, Oberprieler NG. Reduction in Urinary Albumin-to-Creatinine Ratio (UACR) in people with CKD and type 2 diabetes initiating finerenone: a CKD stage subgroup analysis from the FOUNTAIN platform. Poster presented at the American Society of Nephrology (ASN) Kidney Week 2024; October 25, 2024. San Diego, CA. [abstract] J Am Soc Nephrol. 2024 Oct; 35(Suppl v1):559.
BACKGROUND: Evidence from clinical trials demonstrates that finerenone reduces UACR and the risk of adverse cardiovascular and renal outcomes among people with CKD and T2D. Here we aim to describe the change in UACR across subgroups of users of other medications in people initiating finerenone in clinical practice in the United States.
Johannes CB, Ziemiecki R, Pladevall-Vila M, Ebert N, Kovesdy CP, Thomsen RW, Baak BN, Garcia-Sempere A, Kanegae H, Coleman CI, Walsh M, Andersen IT, Rodriguez Bernal C, Robles Cabaninas C, Christiansen CF, Farjat AE, Gay A, Gee P, Herings RMC, Hurtado I, Kashihara N, Kristensen FPB, Liu F, Okami S, Overbeek JA, Penning-van Beest FJA, Yamashita S, Yano Y, Layton JB, Vizcaya D, Oberprieler NG. Clinical profile and treatment adherence in patients with type 2 diabetes and chronic kidney disease who initiate an SGLT2 inhibitor: a multi-cohort study. Diabetes Ther. 2025 Feb;16(2):205-26. doi: 10.1007/s13300-024-01671-x
Gelsey FT, Schapiro D, Kosa K, Vass CM, Perez-Nieves M, Pierce A, Poon JL, DiBenedetti D, Mansfield C. Perspectives and preferences of people with type 2 diabetes for the attributes of weekly insulin. Diabetes Ther. 2024 Nov;15(11):2367-79. doi: 10.1007/s13300-024-01652-0
INTRODUCTION: Daily insulin administration can be burdensome for people with type 2 diabetes (PwT2D) and can impact treatment adherence. This study investigated preferences for once-weekly, long-acting basal insulin for treatment of PwT2D.
Clemmet T, Basarir H, Buompensiere MI, Chrastecka N, de Portu S, Dias RP, Dunne JL, del Pozo CH, Mader JK, Narendran P, Nicholls C, Alsaleh AJO, Piemonti L, Vercauteren J, Mahieu A. Economic evaluations of screening in pre-symptomatic type 1 diabetes (T1D): a systematic literature review. Poster presented at the Immunology of Diabetes (IDS) Congress 2024; November 4, 2024. Bruges, Belgium.
Kovesdy CP, Layton JB, Thapa BB, Curhan GC, Rangel LM, Farjat AE, Liu F, Johannes CB, Vizcaya D, Oberprieler NG. Reduction in Urinary Albumin-to-Creatinine Ratio (UACR) in people with CKD and type 2 diabetes initiating finerenone: a comedication subgroup analysis from the FOUNTAIN platform. Poster presented at the American Society of Nephrology (ASN) Kidney Week 2024; October 24, 2024. San Diego, CA. [abstract] J Am Soc Nephrol. 2024 Oct; 35(Suppl v1):559.
BACKGROUND: Evidence from clinical trials demonstrates that finerenone reduces UACR and the risk of adverse cardiovascular and renal outcomes among people with CKD and T2D. Here we aim to describe the change in UACR across subgroups of users of other medications in people initiating finerenone in clinical practice in the United States.
Oberprieler NG, Kovesdy CP, Layton JB, Thapa B, Curhan G, Farjat AE, Liu F, Johannes C, Vizcaya D. Clinical outcomes in US patients initiating finerenone – a report from the FOUNTAIN platform. Poster presented at the 61st European Renal Association (ERA) Congress; May 2024. Stockholm, Germany. [abstract] Nephrol Dial Transplant. 2024 May; 39(Suppl 1):i2271.
BACKGROUND AND AIMS: Evidence from clinical trials demonstrates that finerenone reduces the risk of cardiovascular and renal complications among patients with chronic kidney disease (CKD) and type 2 diabetes (T2D). What is lacking is the evidence on finerenone use in real-world clinical practice.
Danysh HE, Gilsenan A, Kaye JA, Garcia de Albeniz Martinez X, Schmid R, Bartsch J, Calingaert B, Rahman S, Layton JB, Gutierrez L. Validation of algorithms to identify breast cancer and bladder cancer among patients with type 2 diabetes mellitus in United States medicare administrative claims. Poster presented at the 2024 ISPE Annual Meeting; August 28, 2024. Berlin, Germany.
BACKGROUND: In an ongoing postauthorization drug safety study, we evaluated the validity of algorithms to identify cancer outcomes among individuals with type 2 diabetes mellitus (T2DM) taking a glucose-lowering drug (GLD) in the United States (US) Medicare administrative claims database.